Defining Hiv-1 Reservoirs in the Central Nervous System

HIV transcription persists in the brain of virally suppressed people with HIV

Janna Jamal Eddine, Thomas A Angelovich, Jingling Zhou, Sarah J Byrnes, Carolin Tumpach, Nadia Saraya, Emily Chalmers, Rory A Shepherd, Abigail Tan, Stephanie Marinis, Paul R Gorry, Jacob D Estes, Bruce J Brew, Sharon R Lewin, Sushama Telwatte, Michael Roche, Melissa J Churchill

2024-08-01

HIV persistence in the brain is a barrier to cure, and potentially contributes to HIV-associated neurocognitive disorders. Whether..

Regional Analysis of Intact and Defective HIV Proviruses in the Brain of Viremic and Virally Suppressed People with HIV

TA Angelovich, CR Cochrane, J Zhou, C Tumpach, SJ Byrnes, J Jamal Eddine, E Waring, K Busman-Sahay, C Deleage, TA Jenkins, AC Hearps, S Turville, PR Gorry, SR Lewin, BJ Brew, JD Estes, M Roche, MJ Churchill

2023-10-01

Here, we provide the first regional analysis of intact and defective HIV reservoirs within the brain. Brain tissue from both virem..

Adaptation of the intact proviral DNA assay to a nanowell-based digital PCR platform

C Tumpach, CR Cochrane, Y Kim, J Ong, A Rhodes, TA Angelovich, MJ Churchill, SR Lewin, S Telwatte, M Roche

2023-06-01

Quantification of intact proviruses is a critical measurement in HIV cure studies both in vitro and in vivo. The widely adopted ‘i..

Intact HIV Proviruses Persist in the Brain Despite Viral Suppression with ART

CR Cochrane, TA Angelovich, SJ Byrnes, E Waring, AC Guanizo, GS Trollope, J Zhou, J Vue, L Senior, E Wanicek, JJ Eddine, MJ Gartner, TA Jenkins, PR Gorry, BJ Brew, SR Lewin, JD Estes, M Roche, MJ Churchill

2022-10-01

Objective: Human immunodeficiency virus (HIV) persistence in blood and tissue reservoirs, including the brain, is a major barrier ..